Jesse, Tulip, and Cassidy, still on their quest to find God, are pursued by a relentless gunman, The Saint of Killers. In a casino, they encounter Fiore, an angel, performing as 'The Amazing Ganesh'. Fiore reveals he hired The Saint to destroy Genesis, a powerful entity within Jesse, but is disillusioned and unwilling to help them. Cassidy tries to persuade Fiore, discussing their past and Deblanc's death. Meanwhile, Tulip kills Gary, a figure from her past, to protect Jesse. Jesse proposes to Tulip, but she ultimately declines. Fiore agrees to call off The Saint but won't assist with Eugene in Hell. The group decides to head to New Orleans, following a lead that God loves jazz. Fiore, after a final performance, chooses death, ending his earthly presence.